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Duovir combination of lamivudine and zidovudine is used to treat human immunodeficiency virus (HIV) in patients with or without acquired immunodeficiency syndrome (AIDS). Duovir Lamivudine and zidovudine are in a class of antiviral medications called synthetic nucleoside analogues. Duovir work by slowing the spread of HIV infection in the body. Lamivudine and zidovudine is not a cure and may not decrease the number of HIV-related illnesses.Duovir Lamivudine and zidovudine does not prevent the spread of HIV to other people.